CV Christiane Wolz

 

Christiane Wolz did her PhD on Pseudomonas aeruginosa epidemiology and gene regulation in Tübingen. After her postdoctorate at the Rockefeller University she focused her research on the major human pathogen Staphlyococus aureus. She is affiliated with the Tübingen DFG-funded Clusters of Excellence “CMFI – Controlling Microbes to Fight Infection (EXC 2124). She is mainly interested in the regulatory mechanisms and selective forces that influence the virulence, adaptation and in vivo survival of S. aureus.

Selected Publications:

  1. George SE, Hrubesch J, Breuing I, Vetter N, Korn N, Hennemann K, Bleul L, Willmann M, Ebner P, Gotz F, Wolz C (2019) Oxidative stress drives the selection of quorum sensing mutants in the Staphylococcus aureus population. Proc Natl Acad Sci U S A 116:19145-19154.
  2. Keinhorster D, Salzer A, Duque-Jaramillo A, George SE, Marincola G, Lee JC, Weidenmaier C, Wolz C (2019) Revisiting the regulation of the capsular polysaccharide biosynthesis gene cluster in Staphylococcus aureus. Mol Microbiol 112:1083-1099.
  3. Gerlach D, Guo Y, De Castro C, Kim SH, Schlatterer K, Xu FF, Pereira C, Seeberger PH, Ali S, Codee J, Sirisarn W, Schulte B, Wolz C, Larsen J, Molinaro A, Lee BL, Xia G, Stehle T, Peschel A (2018) Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature 563:705-709.
  4. Gratani FL, Horvatek P, Geiger T, Borisova M, Mayer C, Grin I, Wagner S, Steinchen W, Bange G, Velic A, Macek B, Wolz C (2018) Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus . PLoS Genet 14:e1007514.
  5. Wanner S, Schade J, Keinhorster D, Weller N, George SE, Kull L, Bauer J, Grau T, Winstel V, Stoy H, Kretschmer D, Kolata J, Wolz C, Broker BM, Weidenmaier C (2017) Wall teichoic acids mediate increased virulence in Staphylococcus aureus . Nat Microbiol 2:16257.
  6. Marincola G, Wolz C (2017) Downstream element determines RNase Y cleavage of the saePQRS operon in Staphylococcus aureus . Nucleic Acids Res 45:5980-5994.
  7. Hanzelmann D, Joo HS, Franz-Wachtel M, Hertlein T, Stevanovic S, Macek B, Wolz C, Gotz F, Otto M, Kretschmer D, Peschel A (2016) Toll-like receptor 2 activation depends on lipopeptide shedding by bacterial surfactants. Nat Commun 7:12304.
  8. Munzenmayer L, Geiger T, Daiber E, Schulte B, Autenrieth SE, Fraunholz M, Wolz C (2016) Influence of Sae-regulated and Agr-regulated factors on the escape of Staphylococcus aureus from human macrophages. Cell Microbiol 18:1172-1183.
  9. George SE, Nguyen T, Geiger T, Weidenmaier C, Lee JC, Liese J, Wolz C (2015) Phenotypic heterogeneity and temporal expression of the capsular polysaccharide in Staphylococcus aureus. Mol Microbiol 98:1073-1088.
  10. Geiger T, Francois P, Liebeke M, Fraunholz M, Goerke C, Krismer B, Schrenzel J, Lalk M, Wolz C (2012) The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression. PLoS Pathog 8:e1003016