CV Alyssa Ingmundson


Alyssa Ingmundson studied at the University of Georgia with a focus on microbiology and cellular biology. She completed her doctoral studies at Yale University and received her PhD in microbiology in 2008 studying how Legionella pneumophila effector proteins influence the cell biology of host cells. In 2009 she was awarded the Human Frontier Science Program Postdoctoral Fellowship to pursue research on Plasmodium parasites at the Max Planck Institute for Infection Biology in Berlin. During her post-doctoral studies, she identified Plasmodium proteins that are exported to host cells during infection and characterized the remodeling of host cell-localized membranes by Plasmodium parasites in both the liver and blood stages of infection.

In 2015 Alyssa Ingmundson became a researcher in the department of Molecular Parasitology at the Humboldt University Berlin where she leads a research group investigating host-parasite interactions. Her group focuses on characterizing parasite factors and host processes that contribute to Plasmodium growth and development in the intracellular stages of the life cycle.

Selected Publications:

  1. Putrianti ED, Schmidt-Christensen A, Heussler V, Matuschewski K, Ingmundson A (2020) A Plasmodium cysteine protease required for efficient transition from the liver infection stage. PLoS Pathog 16:e1008891.
  2. Nyboer B, Heiss K, Mueller AK, Ingmundson A (2018) The Plasmodium liver-stage parasitophorous vacuole: A front-line of communication between parasite and host. Int J Med Microbiol 308:107-117.
  3. Petersen W, Stenzel W, Silvie O, Blanz J, Saftig P, Matuschewski K, Ingmundson A (2017) Sequestration of cholesterol within the host late endocytic pathway restricts liver-stage Plasmodium development . Mol Biol Cell 28:726-735.
  4. Petersen W, Külzer S, Engels S, Zhang Q, Ingmundson A, Rug M, Maier AG, Przyborski JM (2016) J-dot targeting of an exported HSP40 in Plasmodium falciparum-infected erythrocytes. Int J Parasitol 46:519-525.
  5. Matz JM, Goosmann C, Brinkmann V, Grützke J, Ingmundson A, Matuschewski K, Kooij TW (2015) The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions. Sci Rep 5:12532.
  6. Petersen W, Matuschewski K, Ingmundson A (2015) Trafficking of the signature protein of intra-erythrocytic Plasmodium berghei-induced structures, IBIS1, to P. falciparum Maurer's clefts. Mol Biochem Parasitol 200:25-29.
  7. Matz JM, Ingmundson A, Costa Nunes J, Stenzel W, Matuschewski K, Kooij TW (2015) In Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence. Eukaryot Cell 14:528-534.
  8. Grützke J, Rindte K, Goosmann C, Silvie O, Rauch C, Heuer D, Lehmann MJ, Mueller AK, Brinkmann V, Matuschewski K, Ingmundson A (2014) The spatiotemporal dynamics and membranous features of the Plasmodium liver stage tubovesicular network. Traffic 15:362-382.
  9. Ingmundson A, Nahar C, Brinkmann V, Lehmann MJ, Matuschewski K (2012) The exported Plasmodium berghei protein IBIS1 delineates membranous structures in infected red blood cells. Mol Microbiol 83:1229-1243.
  10. Ingmundson A, Delprato A, Lambright DG, Roy CR (2007) Legionella pneumophila proteins that regulate Rab1 membrane cycling. Nature 450:365-369.