CV Andreas Müller


Andreas Müller studied biology at ETH Zurich and obtained his PhD in the research group of Wolf-Dietrich Hardt on the topic of inflammasome activation by Salmonella effector proteins, and on the study of bacterial invasion by intravital microscopy in living tissue. Between 2010 and 2013, Andreas Müller conducted postdoctoral research at the Institut Pasteur in Paris in the laboratory of Philippe Bousso on the dynamics of T-cell effector functions in Leishmania major infection, and specialized in the application of biosensors for measuring pathogen physiology by intravital 2-photon microscopy.

After a short research stay at the University of Lausanne in the group of Fabienne Tacchini-Cottier on neutrophil interaction with Leishmania, he was appointed to the W2 professorship "Intravital Microscopy of Infection and Immunity" jointly held at the Institute of Molecular and Clinical Immunology of Otto von Guericke University Magdeburg and the Helmholtz Centre for Infection Research Braunschweig. In addition to the role of pathogen proliferation for immune cell interaction with Leishmania major, he is working here on the role of neutrophils in Staphylococcus aureus infection. Since 2021 Andreas Müller is head of the department "Experimental Immunodynamics" affiliated to the Institute of Molecular and Clinical Immunology.
Within the priority program, his research group, in collaboration with Ger van Zandbergen's group, will investigate the relationship between the triggering of cell death, pathogen growth, and the exit of L. major from the infected cell.

Selected publications:

  1. Dudeck J, Kotrba J, Immler R, Hoffmann A, Voss M, Ismini Alexaki V, Morton L, Jahn SR, Katsoulis-Dimitriou K, Winzer S, Kollias G, Fischer T, Nedospasov SA, Dunay IR, Chavakis T, Müller AJ, Schraven B, Sperandio M, and Dudeck A (2021) Directional mast cell degranulation of TNF into blood vessels primes neutrophil extravasation. Immunity 54:468-483.e5.
  2. Seiß EA, Krone A, Formaglio P, Goldmann O, Engelmann S, Schraven B, Medina E, Müller AJ (2019) Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils. Sci Rep 9:5703.
  3. Heyde S, Philipsen L, Formaglio P, Fu Y, Baars I, Höbbel G, Kleinholz C, Seiß EA, Stettin J, Gintschel P, Dudeck A, Bousso P, Schraven B, Müller AJ (2018) CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission. PLoS Pathog 14:e1007374.
  4. Glodde N, Bald T, Boorn-Konijnenberg D, Nakamura K, Szczepanski S, Brandes M, Eickhoff S, Shridhar N, Hinze D, Rogava M, van der Sluis T, Ruotsalainen J, Gaffal G, Landsberg J, Ludwig K, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Janzen V, Kastenmüller W, Smyth M, Mazzone M, Tüting T, Hölzel M (2017) Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. Immunity 47:789-802.
  5. Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kastle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ (2017) De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling. Sci Signal 10:eaaf4736.
  6. Olekhnovitch R, Ryffel B, Müller AJ*, Bousso P (2014) Collective nitric oxide production provides tissue-wide immunity during Leishmania infection. J Clin Invest 124:1711-1722.
  7. Müller AJ*, Aeschlimann S, Olekhnovitch R, Dacher M, Spath GF, Bousso P (2013) Photoconvertible Pathogen Labeling Reveals Nitric Oxide Control of Leishmania major Infection In Vivo via Dampening of Parasite Metabolism. Cell Host Microbe 14:460-467.
  8. Müller AJ*, Filipe-Santos O, Eberl G, Aebischer T, Spath GF, Bousso P (2012) CD4(+) T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation. Immunity 37: 147-157
  9. Müller AJ, Kaiser P, Dittmar KE, Weber TC, Haueter S, Endt K, Songhet P, Zellweger C, Kremer M, Fehling HJ, Hardt WD (2012) Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes. Cell Host Microbe 11:19-32.
  10. Müller AJ, Hoffmann C, Galle M, Van Den Broeke A, Heikenwalder M, Falter L, Misselwitz B, Kremer M, Beyaert R, Hardt WD (2009) The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation. Cell Host Microbe 6:125-136.