CV Dagmar Heuer


Dagmar Heuer studied human biology at the Phillipps University in Marburg. During her diploma work, she analyzed the importance of N-glycosylation on the functions of the hemagglutinin of avian influenza viruses under the supervision of Prof. Dr. Klenk. After finishing her studies, she focused Chlamydia species, a family of obligate intracellular bacterial pathogens, to gain a deeper understand of the intricate interplay of bacterial pathogens with their host cells. Therefore, she started to work with Prof. Thomas F. Meyer at the Max Planck Institute for Infection Biology (MPIIB)in Berlin. In December 2004, she received her PhD and in 2006 Dagmar Heuer became a team leader of the “Intracellular accommodation of pathogens”-team at the MPIIB. From 2006 to 2010, Dagmar Heuer and her team focused on understanding how pathogens such as Chlamydia trachomatis modulate the host cell trafficking pathways to compete for essential nutrients including sphingolipids.

For her work on the relation between structure and function of the cellular Golgi apparatus in Chlamydia infections, Dagmar Heuer received the “Förderpreis” of the German Society for Hygiene and Microbiology (DGHM) in 2010. In 2011, she was appointed a junior group leader at the Robert Koch Institute (RKI) in Berlin. At the RKI, Dagmar Heuer applied high-throughput proteomics and bioinformatic tools to dissect the sophisticated bacterial-host cell interaction at the bacterial intracellular niche, the inclusion. Since 2017, Dagmar Heuer serves as head of the unit “Sexually transmitted bacterial pathogens” and became interested in understanding therapeutic failure in Chlamydia trachomatis and Neisseria gonorrhoeae infections also performing a German-wide molecular surveillance of the development of antimicrobial resistance in Neisseria gonorrhoeae including genotype-to-phenotype analysis.

Selected Publications:

  1. Banhart S, Schafer EK, Gensch JM, Heuer D (2019) Sphingolipid Metabolism and Transport in Chlamydia trachomatis and Chlamydia psittaci Infections. Front Cell Dev Biol 7:223.
  2. Koch-Edelmann S, Banhart S, Saied EM, Rose L, Aeberhard L, Laue M, Doellinger J, Arenz C and Heuer D (2017) The cellular ceramide transport protein CERT promotes Chlamydia psittaci infection and controls bacterial sphingolipid uptake. Cell Microbiol 19:e12752.
  3. Aeberhard L, Banhart S, Fischer M, Jehmlich N, Rose L, Koch S, Laue M, Renard BY, Schmidt F, Heuer D (2015) The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components." PLoS Pathog 11:e1004883.
  4. Grützke J, Rindte K, Goosmann C, Silvie O, Rauch C, Heuer D, Lehmann MJ, Mueller AK, Brinkmann V, Matuschewski K, Ingmundson A (2014) The spatiotemporal dynamics and membranous features of the Plasmodium liver stage tubovesicular network. Traffic 15:362-382.
  5. Banhart S, Saied EM, Martini A, Koch S, Aeberhard L, Madela K, Arenz C, Heuer D (2014) Improved plaque assay identifies a novel anti-Chlamydia ceramide derivative with altered intracellular localization. Antimicrob Agents Chemother 58:5537-5546.
  6. Heymann J, Rejman Lipinski A, Bauer B, Meyer TF, Heuer D (2013) Chlamydia trachomatis infection prevents front-rear polarity of migrating HeLa cells. Cell Microbiol 15:1059-1069.
  7. Christian JG, Heymann J, Paschen SA, Vier J, Schauenburg L, Rupp J, Meyer TF, Hacker G, Heuer D (2011) Targeting of a chlamydial protease impedes intracellular bacterial growth. PLoS Pathog 7:e1002283.
  8. Karlas A, Machuy N, Shin Y, Pleissner KP, Artarini A, Heuer D, Becker D, Khalil H, Ogilvie LA, Hess S, Maurer AP, Muller E, Wolff T, Rudel T, Meyer TF (2010) Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 463:818-822.
  9. Rejman Lipinski, A, Heymann J, Meissner JC, Karlas A, Brinkmann V, Meyer TF, Heuer D (2009) Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation. PLoS Pathog 5:e1000615.
  10. Heuer D, Rejman Lipinski A, Machuy N, Karlas A, Wehrens A, Siedler F, Brinkmann V, Meyer TF (2009) Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction. Nature 457:731-735.