CV Mathias Hornef


Mathias Hornef studied medicine at the Karl-Eberhard-University Tübingen, the Medical School Lübeck, the Mt. Sinai Medical School, New York, USA, and the Centre Hôspitalier Universitaire Vaudois (CHUV) in Lausanne, Switzerland. He then worked as a research assistant and medical microbiologist at the Max von Pettenkofer Institute of the Ludwig-Maximilian-University Munich. During that time, he worked on the role of type 3 secretion systems and translocated effector molecules during the pathogenesis of infections with Yersinia enterocolitica and Pseudomonas aeruginosa.

In 2000 he became postdoctoral fellow supported by a scholarship of the German Research Foundation and later a postdoctoral fellowship from the Karolinska Institute in the group of Staffan Normark at the Microbiology and Tumor Biology Center (MTC) at Karolinska Institute in Stockholm. There he worked on enteric antimicrobial peptides and innate immune recognition by intestinal epithelial cells. 2002 he became assistant professor with a scholarship from the Swedish Research Foundation.

In 2003, he joined the Institute of Medical Microbiology and Hygiene of the Albert-Ludwig-University Freiburg. There, he completed his specialization as medical microbiologist and started his own research group. 2007 he moved with his group as associate professor for Molecular Microbiology to Hannover Medical School and 2014 as full professor and head of the Institute of Medical Microbiology to the RWTH University Aachen. During the last years he has worked with his group on the establishment of neonatal gastrointestinal infection models with bacterial, viral and parasitic pathogens as well as the postnatal establishment of the enteric microbiota and the maturation of the mucosal adaptive immune system after birth.

Selected Publications:

  1. Riba A, Hassani K, Walker A, van Best N, von Zeschwitz D, Anslinger T, Sillner S, Rosenhain S, Eibach D, Maiga-Ascofaré O, Rolle-Kampczyk U, Basic M, Binz A, Mocek S, Sodeik B, Bauerfeind R, Mohs A, Trautwein C, Kießling F, May J, Klingenspor M, Gremse F, Schmitt-Kopplin P, Bleich A, Torow N, von Bergen M, Hornef MW (2020) Disturbed bile homeostasis and microbiota composition by intestinal protozoan infection causing metabolic dysregulation and growth impairment. Sci Transl Med 12:eaay7019.
  2. van Best N, Rolle-Kampczyk U, Schaap FG, Basic M, Olde Damink S, Bleich A, Savelkoul P, von Bergen M, Penders J*, Hornef MW* (2020) Bile acids drive the newborn’s gut microbiota maturation. Nat Comm 11: 3692.
  3. Fulde M, Sommer F*, Chassaing B*, van Vorst K, Dupont A, Hensel M, Basic M, Klopfleisch R, Rosenstiel P, Bleich A, Bäckhed F, Gewirtz AT, Hornef MW (2018) Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition. Nature 560:489-493.
  4. Zhang K, Riba A, Nietschke M, Torow N, Repnik U, Pütz A, Fulde M, Dupont A, Hensel M, Hornef MW (2018) Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo. PLoS Pathog 14:e1006925.
  5. Torow N, Yu K, Hassani K, Bleich A, Lochner M, Brenneke A, Weiss S, Förster R, Pabst O, Hornef MW (2015) Active suppression of intestinal CD4+TCRαβ+ T lymphocyte maturation during the postnatal period. Nat Comm 6:7725.
  6. Pott J, Mahlakõiv T, Mordstein M, Duerr CU, Michiels T, Stockinger S*, Staeheli P*, Hornef MW* (2011) IFN-lambda determines the intestinal epithelial antiviral host defense. Proc Natl Acad Sci U S A 108:7944-7949.
  7. Chassin C, Kocur M, Pott J, Duerr CU, Gütle D, Lotz M, Hornef MW (2010) miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8:358-368.
  8. Ménard S, Förster V, Lotz M, Gütle D, Duerr CU, Gallo RL, Henriques-Normark B, Pütsep K, Andersson M, Glocker EO, Hornef MW (2008) Developmental switch of intestinal antimicrobial peptide expression. J Exp Med 205:183-193.
  9. Lotz M, Gütle D, Ménard S, Walther S, Bogdan C, Hornef MW (2006) Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med 203:973-984.
  10. Hornef MW, Pütsep K, Karlsson J, Refai E, Andersson M (2004) Increased variability of intestinal antimicrobial peptides by covalent dimer formation. Nat Immunol 5:836-843.