CV Monica Hagedorn

 

CV Monica Hagedorn

Monica Hagedorn studied biology at the University of Ulm with a focus on cell biology. She conducted her diploma thesis at the Whitney Institute, University of Gainesville (Florida). After a short research stay at the University of Auckland, New Zealand she received her PhD in electron microscopy from the University of Ulm in 2003 with the topic "Epithelial calcium transport in the sternal epithelium of the terrestrial isopod Porcellio scaber".

From 2004 to 2010, Monica Hagedorn was a postdoctoral fellow in the group of Prof. T. Soldati. There she established the amoeba Dictyostelium discoideum as a model system to study mycobacterial infections. During this time, she discovered the ejectosome structure that allows nonlytic egress of bacteria from their host cell in this system.

In 2010, Monica Hagedorn returned to Germany and led her own research group at the Bernhard Nocht Institute for Tropical Medicine in Hamburg. There she deepened the work on the egress structure and established Dictyostelium as a host system for Francisella bacteria. Since 2017, she has been working as a researcher at Jacobs University Bremen gGmbH in the research group of Prof. Dr. Hammann. She continues to work there on Dictyostelium as a host system, including for viruses. In 2022, Monica Hagedorn moved to HMU Potsdam.


Selected publications:

  1. Kjellin J, Pränting M, Bach F, Vaid R, Edelbroek B, Li Z, Hoeppner MP, Grabherr M, Isberg RR, Hagedorn M, Söderbom F (2019) Investigation of the host transcriptional response to intracellular bacterial infection using Dictyostelium discoideum as a host model. BMC Genomics 20:961.
  2. Lopez-Jimenez AT, Cardenal-Munoz E, Leuba F, Gerstenmaier L, Barisch C, Hagedorn M, Kind JS, Soldati T (2018) The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection. PLOS Pathog 14:e1007501.
  3. Diesend S, Kruse J, Hagedorn M, Hammann C (2018) Amoebae, giant viruses and virophages make up a complex, multilayered threesome. Front Cell Infect Microbiol 7:527.
  4. Cardenal-Muñoz E, Arafah , López-Jiménez AT, Kicka S, Falaise A, Bach F, Schaad O, King JS, Hagedorn M , Soldati T (2017) Mycobacterium marinum antagonistically induces an autophagic response while repressing the autophagic flux in a TORC1- and ESX-1-dependent manner. PLoS Pathog 13:e1006344.
  5. Klionsky DJ,...Hagedorn M,... et al. (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222.
  6. Barisch C, Paschke P, Hagedorn M, Maniak M, Soldati T (2015) Lipid droplet dynamics at early stages of Mycobacterium marinum infection in Dictyostelium . Cell Microbiol 7:1332-1349.
  7. Gerstenmaier L, Pilla R, Herrmann L, Herrmann H, Prado M, Villafano GJ, Kolonko M, Reimer R, Soldati T, King JS, Hagedorn M (2015) The autophagic machinery ensures nonlytic transmission of mycobacteria. Proc Natl Acad Sci U S A 112:E687-692.
  8. Friedrich N, Hagedorn M, Soldati-Favre D, Soldati T (2012) Prison break: pathogens’ strategies to egress from host cells. Mircobiol Mol Biol Rev 76:707-720.
  9. Hagedorn M, Rohde KH, Russell DG, Soldati T (2009) Infection by tubercular mycobacteria is spread by non-lytic ejection from their amoeba host crucial. Science 323:1729-1733.
  10. Hagedorn M, Soldati T (2007) Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum. Cell Microbiol 9:2716-2733.