CV Nishith Gupta


Nishith Gupta studied biology at the Rohilkhand University of Bareilly, India as well as biotechnology at the Banaras Hindu University of Varanasi, India. He obtained his Master of Science in 1999. In 2003, he obtained his PhD from the University of Leipzig for his work in microbial biochemistry. Following he spent 3 years at the National Jewish Medical and Research Center in Denver, USA as a post-doctoral fellow. Since his research focuses on molecular parasitology. He returned to Germany in 2006 and worked as a research associate at the Humboldt University of Berlin. Since 2009 he heads the research group Molecular Prasitology at the Humboldt-University of Berlin. Since 2016 he is appointed as a Heisenberg Group leader at the same research group.

In 2017 Nishith Gupta habilitated at the Humboldt University in the field of biochemistry and molekular parasitology. His research focuses on metabolic interactions between intracellular parasites and host cells, cyclic nucleotide and calcium signaling, optobiology as well as the development and application of new tools to study parasite-host interactions.

Selected Publications:

  1. Chen K, Günay-Esiyok Ö, Klingeberg M, Marquardt S, Günther-Pomorski T, Gupta N (2021) Aminoglycerophospholipid flipping and P4-ATPases in Toxoplasma gondii. J Biol Chem 296:100315.
  2. Ren B, Schmid M, Scheiner M, Mollenkopf HP, Lucius R, Heitlinger E, Gupta N (2021) Toxoplasma and Eimeria co-opt the host cFos and its network proteins in mammalian cells. Comput Struct Biotechnol 19:719-731.
  3. Vo KC, Günay-Esiyok Ö*, Liem N, Gupta N (2020) The protozoan parasite Toxoplasma gondii encodes a gamut of phosphodiesterases during its lytic cycle in human cells. Comput Struct Biotechnol J 18:3861-387.
  4. Ren B, Kong P, Hedar F, Brouwers JF, Gupta N (2020) Phosphatidylinositol synthesis, its selective salvage, and inter-regulation of anionic phospholipids in Toxoplasma gondii. Commun Biol 3: 750
  5. Günay-Esiyok Ö, Scheib U, Noll M, Gupta N (2019) An unusual and vital protein with guanylate cyclase and P4-ATPase domains in a pathogenic protist. Life Sci Alliance 2:e201900402.
  6. Arroyo-Olarte RD, Thurow L, Kozjak-Pavlovic V, Gupta N (2018) Illuminating pathogen-host intimacy through optogenetics (Pearl article). PLoS Pathog 14:e1007046.
  7. Kuchipudi A, Arroyo-Olarte RD, Hoffmann F, Brinkmann V, Gupta N (2016) Optogenetic monitoring of the parasite calcium identifies a phosphatidylthreonine-regulated ion homeostasis in Toxoplasma gondii. Microbial Cell 3:215-223.
  8. Arroyo-Olarte RD, Burrowers JF, Kuchipudi A, Helms JB, Biswas A, Dunay IR, Lucius R, Gupta N (2015) Phosphatidylthreonine and lipid-mediated control parasite virulence. PLoS Biol 13:e1002288.
  9. Hartmann A, Arroyo-Olarte RD, Imkeller K, Hegemann P, Lucius R, Gupta N (2013) Optogenetic modulation of cAMP levels in Toxoplasma gondii, J Biol Chem 288:13705-13717.
  10. Blume M, Contreras DR, Landfear S, Fleige T, Soldati DF, Lucius R, Gupta N (2009) Hostderived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. Proc Natl Acad Sci U S A 106:12998-3003.