CV Philipp Henneke


Philipp Henneke completed his medical studies in 1994 and obtained his doctorate one year later at the Free University of Berlin. In 1999, he accepted a postdoctoral position in the Department of Infectious Diseases and Immunology at Boston University. In the following two years, further positions followed at the University of Massachusetts and Harvard Medical School. In 2003, Philipp Henneke moved back to Germany, where he accepted a junior professorship at the Center for Pediatric and Adolescent Medicine in Freiburg. Two years later he habilitated in the field of pediatrics. Since 2012, Philipp Henneke has been Professor of Infection and Immunity at the University Medical Center Freiburg and Head of the Department of Pediatric Infectious Diseases and Rheumatology.

Selected Publications:

  1. Lösslein A, Lohrmann F, Scheuermann L, Gharun K, Kolter J, Forde A, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap M, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P (2021) Monocyte progenitors give rise to multinucleated giant cells. Nat Comm 12:2027.
  2. Kuntz M, Kohlfürst D, Feiterna-Sperling C, Krüger R, Baumann U, Buchtala L, Elling R, Grote V, Hübner J, Hufnagel M, Kaiser-Labusch P, Liese J, Otto EM, Rose M, Schneider C, Schuster V, Seidl M, Sommerburg O, Vogel M, von Bernuth H, Weiß M, Zimmermann T, Nieters A, Zenz W, Henneke P (2020) Risk factors for complicated lymphadenitis caused by nontuberculous mycobacteria in children. Emerg Inf Dis 26:579-586.
  3. Feuerstein R, Forde AJ, Lohrmann F, Kolter J, Ramirez NJ, Zimmermann J, Gomez de Agüero M, Henneke P (2020) Resident macrophages acquire innate immune memory in staphylococcal skin infection. Elife 9:e55602.
  4. Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d'Errico P, Baasch S, Amann L, Masuda T, Losslein A, Gharun K, Meyer-Luehmann M, Waskow C, Franzke C, Grün D, Lammermann T, Prinz TM, Henneke P (2019) A subset of skin macrophages contributes to the surveillance and regeneration of local nerves. Immunity 50:1482-1497.
  5. Gharun K, Senges J, Seidl M, Lösslein A, Kolter J, Lohrmann F, Fliegauf M, Elgizouli M, Alber M, Vavra M, Schachtrup K, Illert AL, Gilleron M, Kirschning CJ, Triantafyllopoulou A, Henneke P (2017) Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells. EMBO Rep 18:2144-2159.
  6. Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, ... Diefenbach A, Henneke P, Triantafyllopoulou A (2016) DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 167:1264-1280.
  7. Elling R, Keller B, Weidinger C, Häffner M, Deshmukh S, Zee I, Speckmann C, Ehl S, Schwarz K, Feske S, Henneke P (2016) Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils. J Allergy Clin Immunol 137:1587-1591.
  8. Pannicke U*, BaumannB*, Fuchs S *, Henneke P*, Rensing A, Rizzi M, Janda A, Hese K,Schlesier M, Holzmann K, Laux C, Rump E, Rosenberg A, Zelinski T, Wirth T, Ehl S, Schroeder M, Schwarz K (2013) Deficiency of innate and acquired immunity caused by an IKBKB mutation. N Engl J Med 369:2504-2514.
  9. Deshmukh S, Kremer B, Freudenberg M, Bauer S, Golenbock D, Henneke P (2011) Macrophages recognize streptococci through bacterial RNA. EMBO Rep 12:71-76.
  10. Santos-Sierra S, Deshmukh S, Kalnitski J, Kuenzi P, Wymann M, Golenbock D, Henneke P (2009) Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 28:2018-2027.