CV Bernhard Hube


Bernhard Hube studied biology at the Georg-August-University Göttingen and received his PhD in 1991. Between 1992 and 1995 he received postdoctoral grants from the German Research Foundation (DFG) and the EU and worked as Honour Research Fellow at the Department for Molecular and Cell Biology, University of Aberdeen, Scotland. During this period he focused his research on secretory proteases of the human pathogenic fungus Candida albicans.

In 1995 Bernhard Hube returned to Germany and worked from 1996 to 2000 as Postdoctoral Researcher and C1 Assistant at the department Applied Molecular Microbiology of Plants (AMP III) at the University of Hamburg. In 2000 he received his Habilitation (subject Molecular Microbiology) at the University of Hamburg. From 2000 to 2006 he was Lecturer (Privatdozent) for Microbiology at the Free University of Berlin and Research Group Leader at the Robert Koch Institut (RKI) in Berlin working on virulence factors of Malassezia furfur, Candida glabrata and C. albicans. From 2006 to 2007 he was leader of the Division FG16 “Mycology” at the RKI.

In 2006 he accepted a call for a W3 Professorship and a Chair for Microbial Pathogenicity at the Friedrich-Schiller University (FSU) Jena. From 2007 he was also Head of Department of the Department Microbial Pathogenicity Mechanisms at the Leibniz-Institute for Natural Product Research and Infection Biology e.V. - Hans-Knoell-Institute (HKI), Jena. The scientific topics of his department are (a) infection biology of human pathogenic fungi (Candida albicans, C. glabrata), (b) host/pathogen-Interactions and (c) functional genomics, microevolution and infection associated genes.

Bernhard Hube is Fellow of the American Academy of Microbiology (AAM), has received the main research award of the Deutschsprachige Mykologische Gesellschaft (DMykG), the Becton Dickinson-Award of the Deutsche Gesellschaft für Hygiene und Mikrobiologie (DGHM), the Heinz Seeliger-Award, ten publication awards of the DMykG (as author or co-author), the Heinz-Maurer-Award (co-author), the main award of the DGHM, an In-House Professurship at the Center for Sepsis Control and Care (CSCC) and the award of the Leibniz-Drug of the Year of the Leibniz Association. He is Honory Member of the DMykG, as well as Editorial Board/Associated Editor for Cellular Microbiology, Current Opinion in Microbiology, FEMS Yeast Research, mBio, Virulence and further journals.

Selected Publications:

  1. Drummond RA, Swamydas M, Oikonomou V, Zhai B, Dambuza I, Schaefer BC, Bohrer AC, Mayer-Barber KD, Lira SA, Iwakura Y, Filler SG, Brown D, Hube B, Naglik JR, Hohl TM, Lionakis MS. (2019) CARD9-Expressing Microglia Promote IL-1b and CXCL1-dependent Neutrophil Recruitment to the Fungal-Infected Central Nervous System. Nature Immunology 20:559-570.
  2. Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A (2019) Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans . Cell 176:1340-1355.e15.
  3. Allert S, Förster TM, Svensson CM, Richardson JP, Pawlik T, Hebecker B, Rudolphi S, Juraschitz M, Schaller M, Blagojevic M, Morschhäuser J, Figge MT, Jacobsen ID, Naglik JR, Kasper L, Mogavero S and Hube B. (2018) Candida albicans-induced epithelial damage mediates translocation through intestinal barriers. mBio 9. pii: e00915-18.
  4. Verma AH, Richardson JP, Zhou C, Coleman BM, Moyes DL, Ho J, Huppler AR, Ramani K, McGeachy MJ, Mufazalov IA, Waisman A, Kane LP, Biswas PS, Hube B, Naglik JR, Gaffen SL (2017) Oral epithelial cells orchestrate innate Type 17 responses to Candida albicans via the virulence factor Candidalysin. Science Immunology 2: pii: eaam8834.
  5. Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krueger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B*, Naglik JR (2016) Candidalysin: A fungal peptide toxin critical for mucosal infection. Nature 532:64-68. *corresponding author.
  6. Citiulo F, Jacobsen ID, Miramón P, Schild L, Brunke S, Zipfel P, Brock M, Hube B, Wilson D (2012) Candida albicans scavenges host zinc via Pra1 during endothelial invasion. PLoS Pathog 12:e1002777.
  7. Mayer FL, Wilson D, Jacobsen ID, Miramón P, Große K, Hube B (2012) The Novel Candida albicans Transporter Dur31 is a Multi-Stage Pathogenicity Factor. PLoS Pathog 8:e1002592.
  8. Dalle F, Wächtler B, L'Ollivier C, Holland G, Bannert N, Wilson D, Labruère C, Bonnin A, Hube B (2010) Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes. Cell Microbiol 12:248-271.
  9. Almeida RS, Brunke S, Albrecht A, Thewes S, Laue M, Edwards JE, Filler SG Jr, Hube B (2008) The hyphal-associated adhesin and invasin Als3 of Candida albicans mediates iron acquisition from host ferritin. PLoS Pathogens 4:e1000217.
  10. Thewes S, Kretschmar M, Park H, Schaller M, Filler S, Hube B (2007) In vivo and ex vivo comparative transcriptional profiling of invasive and non-invasive Candida albicans isolates identifies genes associated with tissue invasion. Mol Microbiol 63:1606-1628.