SPP 2225

  Exit of a P. falciparum gamete from the host erythrocyte Copyright: G. Pradel Exit of a P. falciparum gamete from the host erythrocyte

The Priority Programme SPP 2225 “Exit strategies of intracellular pathogens” was established by the Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) in 2019. The SPP 2225 aims at exploring the spectrum of convergently evolved exit pathways employed by bacterial, parasitic and fungal pathogens with relevance for human health. Knowledge gained by the SPP 2225 will extend our understanding of microbial pathogenesis and help to explore novel targets for future interventional measures to counteract human infectious diseases.

The following types of host cell exit are being investigated within the SPP 2225

  • Exit from the host cell
  • Exit from vacuolar compartment as a prerequisite of host cell exit
  • Exit from a pathogen-containing cyst

The following aspects of host cell exit are being investigated within the SPP 2225

  • The sequential steps of pathogen-specific host cell exit pathways
  • The link between exit pathway and host cell specificity
  • The endogenous and environmental triggers of host cell exit
  • The signalling pathways mediating host cell exit
  • The key molecular mediators, regulators and effectors of host cell exit
  • The cross-taxa conservation and species-specific variation of host cell exit